Research Trial:
Researchers at Monash Medical Centre, Clayton in collaboration with the World Health Organisation are trialing a new male contraceptive method. We need healthy couples living in a stable relationship and not planning pregnancy for two years.
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Recent Publications

Bagheri-Fam, S., Sim, H., Bernard, P., Jayakody, I., Taketo, M.M., Scherer, G. and Harley, V.R. (2008) Loss of Fgfr2 leads to partial XY sex reversal. Developmental Biology 314: 314: 71-83. IF=4.9

Bernard, P., Fleming, A., Lacombe, A., Harley, V.R.* and Vilain, E.J.N. (2007) Wnt4 inhibits (beta)-catenin/TCF signaling by redirecting (beta)-catenin to the cell membrane. Biology of the Cell, in press. IF=4.3; * corresponding author.

Svingen, T., Beverdam, A., Bernard, P., McClive, P., Harley, V.R., Sinclair, A.H. and Koopman, P (2007) Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Reproduction 133: 983-989. IF=3.0

Vilain, E., Achermann, J.C., Eugster, E.A., Harley, V.R., Morel, Y., Wilson, J.D. and Hiort, O. (2007). We used to call them hermaphrodites. Genetics in Medicine 9: 65-66. IF=3.4

Knower, K.C., McClive, P., Bowles, J., Koopman, P., Sinclair, A. and Harley, V.R. (2007) Characterisation of urogenital ridge gene expression in the human embryonal carcinoma cell line NT2/D1. Sexual Development 1: 114-126. New journal.

Bernard, P.A., Ludbrook, L.; Queipo, G., Dinulos; M.-B., Zhang, Y.-H.; Phelan, J.K.; McCabe, E.R.B.; Harley, V.R. and Vilain, E. (2006) A familial missense mutation in the hinge region of DAX1 associated with late-onset AHC in a prepubertal female. Molecular Genetics and Metabolism 88:272-279.

Dewing, P., Chiang, C.W.K., Sinchak, K., Sim, H., Fernagut, P.-O., Kelly, S., Chesselet, M.-F., Micevych, P.E., Albrecht, K.H., Harley, V.R. and Vilain, E. (2006) Direct regulation of adult brain function by the male-specific factor SRY. Current Biology, 16(4):415-420.

Wang, Y., Ristevski, S. and Harley, V.R. (2006) SOX13 exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis and limb development. Journal of Histochemistry and Cytochemistry 54: 1327-1333.

Hughes, I.A., and the LWPES/ESPE Consensus Group (includes V. Harley) (2006) Consensus statement on management of intersex disorders. Archives of Disease in Childhood 91: 554-563.

Houk, C.P., and the LWPES/ESPE Consensus Group (includes V. Harley) (2006) Summary of consensus statement on intersex disorders and their management. International Intersex Consensus Conference. Pediatrics 118: 753-757.

Lee, P.A., and the LWPES/ESPE Consensus Group (includes V. Harley) (2006) Consensus statement on management on intersex disorders. International Consensus Conference on Intersex. Pediatrics 118: 814-815.

Wang, Y., Bagheri-Fam, S. and Harley, V.R. (2005) SOX13 is up-regulated in the developing mouse neuroepithelium and identifies a sub-population of differentiating neurons. Brain Research. Developmental Brain Research 157(2):201-208.

Sim, H., Rimmer, K., Kelly, S., Ludbrook, L.M., Clayton, A.H.A. and Harley, V.R. (2005) Defective calmodulin-mediated nuclear transport of the sex determining region of the Y chromosome (SRY) in XY sex reversal. Molecular Endocrinology 19(7):1884-1892.

Park, D.J., Pask, A.J., Huynh, K., Renfree, M.B., Harley V.R. and Graves, J.M. (2004) Comparative analysis of ATRX, a chromatin remodeling protein. Gene 339:39-48.

Rountree, R.B., Schoor, M., Chen, H., Marks, M.E., Harley, V., Mishina, Y. and Kingsley, D.M. (2004) BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biology 2(11): 1815-1827.

Ludbrook LM, Harley VR. Sex determination: a 'window' of DAX1 activity. Trends Endocrinol Metab. 2004 Apr; 15 (3):116-21

Harley VR, Clarkson M, Argentaro A. (2003) The molecular action and regulation of the testis determining factors, SRY (sex determining region of the Y chromosome) and SOX9 (SRY related high mobility group (HMG) box 9 . Endocrine Reviews24(4) 466-487

Harley VR, Layfield S, Mitchell C, Forwood JK, John AP, Briggs LJ, McDowall S, Jans D. (2003) Defects in importin b recognition and nuclear import of the sex determining factor SRY cause XY sex reversal. Proceedings of the National Academy of Sciences ( USA ) 100, 7045-7050.

Argentaro A, Sim H, Kelly s, Preiss S, Clayton A, Jans DA, Harley VR. (2003) A SOX9 Defect of Calmodulin-dependent Nuclear Import in Campomelic Dysplasia/Autosomal Sex Reversal. JBC278:33839-47 (cover story, Sept 5 issue)

Bernard P, Tang P, Liu S, Dewing P, Harley VR, Vilain E. (2003) Dimerization of SOX9 is required for chondrogenesis, but not for sex determination. Human Molecular Genetics12, 1-11.

Fernández-Lloris R, Viñals F, López-Rovira T, Harley VR, Bartrons R, Rosa JL, Ventura F. Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cells.
Mol Endocrinol. 2003 Jul;17(7):1332-43.

Aigner T, Gebhard PM, Schmid E, Bau B, Harley V, Poschl E. (2003) SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes. Matrix Biology22(4):363-72.