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Male Fertility Regulation
About this Laboratory
Our overall aim is to identify how hormones control sperm production, or spermatogenesis. We approach this problem by first identifying the key hormone-regulated cell types in the testis, and then finding the key proteins and molecules within these cells. This research is central to finding new mechanisms of contraception in men and also in understanding causes of male infertility.
Related to Research Themes
Current Research
Proteomic discovery programme in male reproduction - We aim to identify serum protein markers that reflect cellular processes, such as germ cell differentiation or response to hormones, for use in basic and clinical research in andrology.
Regulation of Sertoli cell junctions - We are investigating the ways in which hormones control junctions between cells in the testis, as these are potential sites of action of male hormonal contraception.
Regulation of sperm release - We are investigating the process of sperm release to aid in the discovery of new, non-hormone-based contraceptives and to better understand some forms of male infertility.