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Growth Factor Signalling
About this Laboratory
The TGF-β family of proteins plays crucial roles throughout development and in the maintenance of tissue homeostasis in adult life. Our group is exploring the mechanisms that govern the availability of active TGF-β ligands and the consequences of dysregulated TGF-β signalling.
Related to Research Themes
Cancer , Genes & Healthy Development
Current Research
Inhibin A and B in the reproductive system - Inhibin A and inhibin B, members of the TGFβ family, are essential regulatory factors in mammalian reproduction. This program aims to determine their mechanisms of action.
TGF-β signalling pathway disorders - Transforming growth factor-β2 (TGF-β2), a member of the TGF-β superfamily, plays important roles in diverse developmental and homeostatic processes. Targeted disruption of TGF-β2 results in perinatal lethality and a wide range of developmental defects. In this project, we are focusing on the molecular interactions that mediate the assembly, secretion, ECM localisation and activation of TGF-β2.
Myostatin and muscular dystrophy - The use of broad-spectrum TGF-β antagonists may be an effective strategy for promoting muscle growth in a variety of myopathies, including Duchenne muscular dystrophy.