Prince Henry’s Institute

 

Kati Matthiesson

 

Profile

Dr Matthiesson completed her PhD thesis at PHI, investigating the hormonal regulation of spermatogenesis. Her work provided important insights into the spermatogenic processes that are responsive to hormones in men, the modes of action of different contraceptive formulations, and the regulation of an important Leydig cell factor, INSL3, in men. Her PhD was awarded in 2006. 

 

Research Interests

Dr Matthiesson maintains a strong clinical focus in both reproductive and general endocrinology. Her ongoing research includes further projects examining the process of spermatogenesis and the WHO / CONRAD sponsored male contraceptive trial.

 

Expertise

Translational research in male reproductive endocrinology.

 

Recent Achievements

• Description of the hormonal profiles of new male contraceptive formulations

• Description of the testicular targets of male hormonal contraception

 

Current Research

• Developing new reversible male contraceptives

 

Selected Publications

Matthiesson KL, McLachlan RI,  O'Donnell L, Frydenberg M, Robertson DM, Stanton PG, , Meachem SJ. 2006 The relative roles of FSH and LH in maintaining spermatogonial populations and spermiation in normal men. J Clin Endocrinol Metab, 91(10):3962-9.

Matthiesson K & McLachlan RI. Male Hormonal Contraception: concept proven, product in sight? Human Reproduction Update 2006, 12:463-82.

Bay K, Matthiesson KL, McLachlan RI, Andersson A-M. The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men.  Journal of Clinical Endocrinology & Metabolism 2006, 91:1108-11.

Matthiesson KL, Stanton PG, O'Donnell L, Meachem SJ, Amory JK, Berger R, Bremner WJ, and McLachlan RI. 2005 Effects of testosterone and levonorgestrel combined with a 5 alpha reductase inhibitor or GnRH antagonist on spermatogenesis and intratesticular steroid levels in normal men. J Clin Endocrinol Metab, 90:5647-5655.

Matthiesson KL, Amory JK, Berger R, Ugoni A, McLachlan RI, Bremner WJ. Novel male hormonal contraceptive combinations: the hormonal and spermatogenic effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist. J Clin Endocrinol Metab. 2005 Jan;90(1):91-7.

Matthiesson KL, Robertson DM, Burger HG, McLachlan RI. Response of serum inhibin  and Pro-alphaC levels to gonadotrophic stimulation in normal men before and after steroidal contraceptive treatment. Human Reproduction 2003, 18:734-43.