Research Trial:
Prince Henry's Institute is seeking non-smoking, healthy but overweight men aged 40-70 years for a study of testosterone treatment on body fat and cardiovascular disease.
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Although oestrogen is often thought of as the “female hormone”, research is now beginning to show that oestrogen is also very important in males, particularly for bone formation as well as for male fertility. Studies with the Breast Cancer Group are investigating male mice that lack the enzyme aromatase which manufactures oestrogen, and thus these mice do not have oestrogen from birth (called the aromatase knockout mouse, or ArKO mouse). Studies reveal that this mouse gradually becomes infertile due to defects in germ cell development. Importantly, our research shows that there is an impairment of sexual behaviour, indicating that oestrogen may in fact be essential for male sexual behaviour. Further studies on male ArKO mice will allow us to elucidate the role of oestrogen in male physiology and behaviour.





















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