Research Trial:
Researchers at Monash Medical Centre, Clayton in collaboration with the World Health Organisation are trialing a new male contraceptive method. We need healthy couples living in a stable relationship and not planning pregnancy for two years.
more details >>

Zhou J, Suzuki T, Kovacic A, Saito R, Miki Y, Ishida T, Moriya T, Simpson ER, Sasano H, Clyne CD. Interactions between prostaglandin E 2, Liver Receptor Homologue-1, and aromatase in breast cancer. Cancer Res . 65:657-63, 2005

Misso ML, Hewitt KN, Boon WC, Murata Y, Jones ME, Simpson ER. Cholesterol feeding prevents adiposity in the obese female aromatase knockout (ArKO) mouse. Horm Metab Res. 37:26-31, 2005

Watanabe M, Simpson ER, Pathirage N, Nakajin S, Clyne CD. Aromatase expression in the human fetal osteoblastic cell line SV-HFO. J Mol Endocrinol 32:533-45, 2004

Clyne CD, Kovacic A, Speed CJ, Zhou J, Pezzi V, Simpson ER. Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue. Mol Cell Endocrinol 215:39-44, 2004

Hill RA, Pompolo S, Jones ME, Simpson ER, Boon WC. Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice. Mol Cell Neurosci 27:466-76, 2004

Pezzi V, Sirianni R, Chimento A, Maggiolini M, Bourguiba S, Delalande C, Carreau S, Ando S, Simpson ER, Clyne CD. Differential expression of steroidogenic factor-1/adrenal 4 binding protein and Liver Receptor Homolog-1 (LRH-1)/Fetoprotein Transcription Factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Endocrinology 145:2186-96, 2004

Hewitt KN, Pratis K, Jones ME, Simpson ER. Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse. Endocrinology. 145:842-8, 2004

Huynh K, Jones G, Thouas G, Britt KL, Simpson ER, Jones ME. Estrogen is not directly required for oocyte developmental competence. Biol Reprod. 70:1263-9, 2004

Maffei L, Murata Y, Rochira V, Tubert G, Aranda C, Vazquez M, Clyne CD, Davis S, Simpson ER, Carani C. Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment. J Clin Endocrinol Metab 89:61-70, 2004

Kovacic A, Speed CJ, Simpson ER, Clyne CD. Inhibition of aromatase transcription via promoter II by short heterodimer partner in human preadipocytes. Mol Endocrinol. 18:252-9, 2004

Hewitt KN, Boon W-C, Murata Y, Jones MEE, Simpson ER. The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis. Endocrinology. 144(9):3895-903, 2003

Jarred RA, McPherson SJ, Jones ME, Simpson ER, Risbridger GP. Anti-androgenic action by red clover-derived dietary isoflavones reduce non-malignant prostate enlargement in aromatase knockout (ArKO) mice. Prostate 56(1):54-64, 2003

Kimura M, Sudhir K, Jones M, Simpson ER, Jefferis A-M, Chin-Dusting JPF. Impaired acetycholine induced release of nitric oxide in the aorta of male aromatase knockout (ArKO) mice: regulation of nitric oxide production by endogenous sex hormones in males. Circ. Res 93:1267-1271, 2003

Martin S, Jones M, Simpson E, van den Buuse M. Impaired spatial reference memory in aromatase-deficient (ArKO) mice. Neuroreport. 27;14(15):1979-82, 2003

McCullough LD, Blizzard K, Simpson ER, Oz OK, Hurn PD. Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci. 23(25):8701-5, 2003

Misso ML, Murata Y, Boon WC, Jones ME, Britt KL, Simpson ER. Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse. Endocrinology 144(4):1474-1480, 2003

Sasano H, Edwards DP, Anderson TJ, Silverberg SG, Evans DB, Santen RJ, Ramage P, Simpson ER, Bhatnagar AS, Miller WR. Validation of new aromatase monoclonal antibodies for immunohistochemistry: progress report. J Steroid Biochem Mol Biol. 86(3-5):239-44, 2003

Simpson ER. Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 86(3-5):225-30, 2003

Sofi M, Young MJ, Papamakarios T, Simpson ER, Clyne CD. Role of CRE-binding (CREB) in aromatase expression in breast adipose. Breast Cancer Res Treat. 79(3):399-407, 2003

van den Buuse M, Simpson ER, Jones ME. Prepulse inhibition of acoustic startle in aromatase knock-out mice: effects of age and gender. Genes Brain Behav. 2(2):93-102, 2003

Weihua Z, Andersson S, Cheng G, Simpson ER, Warner M, Gustafsson JA. Update on estrogen signalling. FEBS Lett. 546(1):17-24, 2003




© Prince Henry's Institute of Medical Research ABN 77 601 754 678 Disclaimer | Links to other sites