Bone, Joint & Cancer
 
 
 
     
 

Research Trial:
Researchers at Monash Medical Centre, Clayton in collaboration with the World Health Organisation are trialing a new male contraceptive method. We need healthy couples living in a stable relationship and not planning pregnancy for two years.
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© Prince Henry's Institute
of Medical Research
ABN 48 132 025 024
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Representative Publications
  1. Bruzzaniti, A., Goodge, K., Jay, P., Taviaux, S.A., Lam, M.H.C., Berta, P., Martin, T.J. Moseley, J.M. and Gillespie, M.T. (1996). PC8 a new member of the convertase family. Biochemical Journal. 314, 727-731.
  2. Udagawa, N., Horwood, N.J., Elliott, J., Mackay, A., Owens, J., Okamura, H., Kurimoto, M., Chambers, T.J., Martin, T.J. and Gillespie, M.T. (1997). A new osteoclastogenic inhibitory factor interleukin (IL)-18 (interferon gamma-inducing factor) is produced by osteoblasts and acts via granulocyte macrophage-colony stimulating factor (GM-CSF) and not via interferon-gamma. Journal of Experimental Medicine. 185, 1005-1012.
  3. Horwood, N.J., Udagawa, N., Elliott, J., Grail, D., Okamura, H., Kurimoto, M., Dunn, A.R., Martin, T.J. and Gillespie, M.T. (1998). Interleukin-18 inhibits osteoclast formation via T-cell production of granulocyte macrophage-colony stimulating factor. Journal of Clinical Investigation. 101, 595-603.
  4. Lam, M., Briggs, L.J., Hu, W., Martin, T.J., Gillespie, M.T. and Jans, D.A. (1999). Importin  recognizes parathyroid hormone-related protein (PTHrP) with high affinity and mediates its nuclear import in the absence of importin . Journal of Biological Chemistry. 274, 7391-7398.
  5. Lam, M.H.C., House, C.M., Tiganis, T., Mitchelhill, K.I., Sarcevic, B., Cures, A., Ramsay, R., Kemp, B.E., Martin, T.J. and Gillespie, M.T. (1999). Phosphorylation at the cyclin dependent kinases p34cdc2 and p33cdk2 site (Thr85) of parathyroid hormone-related protein (PTHrP) negatively regulates its nuclear localization. Journal of Biological Chemistry. 274, 18559-18566.
  6. Thomas, R.J., Guise, T.A., Yin, J.J., Elliott, J., Horwood, N.J., Martin, T.J., and Gillespie, M.T. (1999). Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology. 140, 4451-4458.
  7. Horwood, N.J., Elliott, J., Martin, T.J. and Gillespie, M.T. (2001). Interleukin-12 alone, and in synergy with interleukin-18, inhibits osteoclast formation in vitro. Journal of Immunology. 166, 4915-4921.
  8. Romas, E., Sims, N.A., Hards, D.K., Lindsay, M., Ryan, P.F.J., Quinn, J.M.W., Dunstan, C.R., Martin, T.J. and Gillespie, M.T. (2002). Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. American Journal of Pathology. 161, 1419-1427.
  9. Cingolani, G., Bednenko, J., Gillespie, M.T. and Gerace, L. (2002). Molecular basis for the recognition of a non-classical nuclear localization signal by importin . Molecular Cell. 10, 1345-1353.
  10. Zhou, H., Kartsogiannis, V., Quinn, J.M.W., Ly, C., Gange, C., Elliott, J., Ng, K.W. and Gillespie, M.T. (2002). Osteoclast inhibitory lectin, a family of new osteoclast inhibitors. Journal of Biological Chemistry. 277, 48808-48815.
  11. Frew, I.J., Sims, N.A., Quinn, J.M.W., Walkley, C.R., Purton, L.E., Bowtell, D.D.L. and Gillespie, M.T. (2004). Osteopenia in Siah1a mutant mice. Journal of Biological Chemistry. 279, 29583-29588.
  12. H¦usler, K.D., Horwood, N.J., Chuman, Y., Fisher, J.L., Ellis, J., Martin, T.J., Rubin, J.S. and Gillespie, M.T. (2004). Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. Journal of Bone and Mineral Research. 19, 1873-1881.
  13. Fisher, J.L., Thomas-Mudge, R.J., Elliott, J., Hards, D.K., Sims, N.A., Slavin, J., Martin, T.J. and Gillespie, M.T. Osteoprotegerin over-expression by breast cancer cells enhances orthotopic and osseous tumor growth, and contrasts with that delivered therapeutically. Cancer Research. 66, 3620-3628.